Removing all obstacles: A critical role for p53 in promoting tissue renewal
نویسندگان
چکیده
منابع مشابه
Removing unnecessary obstacles to randomised trials
Since their introduction in the middle of the 20 Century, randomised trials of sufficiently large size have provided reliable assessments of the safety and efficacy of treatments that have produced substantial improvements in health. During the past decade, however, increasingly onerous (albeit well-meaning) regulation and related bureaucracy have made clinical trials much more difficult and co...
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A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.
Throughout life, intestinal Lgr5+ stem cells give rise to proliferating transient amplifying cells in crypts, which subsequently differentiate into one of the five main cell types and migrate along the crypt-villus axis. These dynamic processes are coordinated by a relatively small number of evolutionarily conserved signaling pathways, which includes the Wnt signaling pathway. The DNA-binding p...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.7.11194